Regulation of the aldosterone synthase gene-role in human hypertension and adrenal corticosteroid production

McManus, Frances (2012) Regulation of the aldosterone synthase gene-role in human hypertension and adrenal corticosteroid production. PhD thesis, University of Glasgow.

Abstract

Despite many advances in technology and significant levels of funding, the genetic factors that regulate blood pressure in the population remain unclear. The public health implications of this lack of knowledge are conspicuous and a better understanding of the mechanisms behind hypertension would lead to better management of this important risk factor. The myriad of physiological systems involved in maintaining blood pressure can be variably dysregulated in patients with hypertension. Therefore, taking more account of hypertension as a heterogeneous condition may be a useful approach. Given the lack of success in dissecting the genetic factors to date, it seems reasonable to refocus attention on more carefully phenotyped groups of subjects, with the aim of identifying mechanisms specific to them.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Subjects: R Medicine > R Medicine (General)
• Colleges/Schools: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Supervisor's Name: Davies, Prof. E. and Connell, Prof. J.
• Date of Award: 2012
• Depositing User: Mrs Marie Cairney
• Unique ID: glathesis:2012-3565
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 17 Aug 2012
• Last Modified: 03 Jan 2019 16:52
• URI: https://theses.gla.ac.uk/id/eprint/3565