Differential actions of methlyarginines in the rat aorta

Al-Zobaidy, Mohammed Abdul-Hassan Jabarah (2012) Differential actions of methlyarginines in the rat aorta. PhD thesis, University of Glasgow.

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Abstract

The PhD project is about the Regulation of vascular tone by endothelium. It involves studying the effects of methylated arginine analogues such as monomethyl arginine (L-NMMA) and asymmetric dimethylarginine (ADMA) on nitric oxide (NO) activity in rat aorta using organ baths containing Krebs solution at 37 ˚C and gassed with 95% O2 and 5% CO2. These two inhibitors of endothelial nitric oxide synthase enzyme (eNOS) showed an anomalous action, as they inhibited basal NO activity (assessed by enhancement of phenylephrine-induced tone and by blocking relaxations produced by superoxide dismutase or the PDE5 inhibitor; T0156) but not that is stimulated by agonists like acetylcholine or the calcium ionophore A23187. After establishing these findings I will try to find the reason(s) for these paradoxical actions of these two endogenously synthesized inhibitors of eNOS.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Nitric oxide, Monomethylarginine (L-NMMA), asymmetric dimethylarginine (ADMA).
Subjects: R Medicine > RM Therapeutics. Pharmacology
Colleges/Schools: College of Medical Veterinary and Life Sciences > School of Life Sciences
Funder's Name: UNSPECIFIED
Supervisor's Name: Martin, Prof. William
Date of Award: 2012
Depositing User: Dr MOHAMMED AL-ZOBAIDY
Unique ID: glathesis:2012-3838
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 16 Jan 2013 15:24
Last Modified: 16 Jan 2013 15:24
URI: http://theses.gla.ac.uk/id/eprint/3838

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