Developing Novel Synthetic Methods for the Pauson-Khand Reaction

Blunt, Gillian (2002) Developing Novel Synthetic Methods for the Pauson-Khand Reaction. PhD thesis, University of Glasgow.

Abstract

The Pauson-Khand cyclisation is one of the most useful reactions for the formation of cyclopentenone ring systems. It is a [2 + 2 + 1] cycloaddition between an alkyne, alkene and one molecule of carbon monoxide. The reaction is mediated by dicobalt octacarbonyl. The aim was to develop a general and simple route to generating cyclopentenone ring systems utilising the Pauson-Khand cyclisation. We chose to use amines as promoters as opposed to the more commonly used amine N-oxides. An efficient route to cyclopentenone i was developed. Substrate ii was heated to 50

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: Jennifer Matthews
• Keywords: Organic chemistry
• Date of Award: 2002
• Depositing User: Enlighten Team
• Unique ID: glathesis:2002-76215
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 19 Nov 2019 16:28
• Last Modified: 19 Nov 2019 16:28
• URI: https://theses.gla.ac.uk/id/eprint/76215