Some Statistical Investigations in Human Genetics Linkage

Abdalla, Mona (1989) Some Statistical Investigations in Human Genetics Linkage. PhD thesis, University of Glasgow.

Abstract

The aim of this thesis is to investigate some statistical aspects of techniques developed in genetic linkage analysis. In chapter one we provide the reader with a simplified introduction to some of the basic concepts of genetic linkage which are essential for the understanding of the work developed later, as well as giving a short summary of the relevant work published in the genetical literature. In chapter two and three, the problem of unknown orders of three loci known to be on the same chromosome is studied. Criteria used by the geneticists to test the different orders are mentioned and then studied in various details. In chapter four and five a comparative study between different ways of constructing interval estimates in linkage study are investigated. In chapter four certain methods of approximation for the likelihood function approach are compared under a three loci set up; on the other hand chapter five compares the likelihood and the Bayesian approach under a two loci set up. In chapter six we study the Bayesian approach in providing a point estimate for the probability of an unborn child being at risk of carrying a genetical disease given his family pedigree. Application of this method as opposed to the likelihood approach is presented using an example from the genetical literature. In chapter seven a discussion of the work is presented and possible extensions are suggested.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: A D McLaren
• Keywords: Statistics, Genetics
• Date of Award: 1989
• Depositing User: Enlighten Team
• Unique ID: glathesis:1989-76497
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 19 Nov 2019 14:16
• Last Modified: 19 Nov 2019 14:16
• URI: https://theses.gla.ac.uk/id/eprint/76497