Roles for the VEZF1 transcription factor in erythroid and housekeeping gene expression

Al-Hosni, Aliya M.R. (2017) Roles for the VEZF1 transcription factor in erythroid and housekeeping gene expression. PhD thesis, University of Glasgow.

Due to Embargo and/or Third Party Copyright restrictions, this thesis is not available in this service.

Abstract

VEZF1 is a DNA-binding transcription factor that is highly conserved in vertebrates. Human VEZF1 has recently been found to interact with transcriptionally active gene promoters and erythroid specific enhancers. It is unclear how the broadly expressed VEZF1 interacts with enhancers in a cell type-specific manner or what functions it plays at these elements. This work begins to address the cell-type specific roles of VEZF1 by creating loss of function models in a human erythroid cell line.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH345 Biochemistry
Q Science > QH Natural history > QH426 Genetics
Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences > Translational Research Centre
Funder's Name: UNSPECIFIED
Supervisor's Name: West, Dr. Adam
Date of Award: 2017
Embargo Date: 18 April 2020
Depositing User: Dr Aliya Al-Hosni
Unique ID: glathesis:2017-8118
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 18 Apr 2017 15:55
Last Modified: 26 May 2017 13:11
URI: http://theses.gla.ac.uk/id/eprint/8118

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