Al-Hosni, Aliya M.R. (2017) Roles for the VEZF1 transcription factor in erythroid and housekeeping gene expression. PhD thesis, University of Glasgow.
Due to Embargo and/or Third Party Copyright restrictions, this thesis is not available in this service.
Printed Thesis Information: https://eleanor.lib.gla.ac.uk/record=b3268933
Abstract
VEZF1 is a DNA-binding transcription factor that is highly conserved in vertebrates. Human VEZF1 has recently been found to interact with transcriptionally active gene promoters and erythroid specific enhancers. It is unclear how the broadly expressed VEZF1 interacts with enhancers in a cell type-specific manner or what functions it plays at these elements. This work begins to address the cell-type specific roles of VEZF1 by creating loss of function models in a human erythroid cell line.
| Item Type: | Thesis (PhD) |
|---|---|
| Qualification Level: | Doctoral |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH345 Biochemistry Q Science > QH Natural history > QH426 Genetics |
| Colleges/Schools: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences > Translational Research Centre |
| Supervisor's Name: | West, Dr. Adam |
| Date of Award: | 2017 |
| Embargo Date: | 18 April 2021 |
| Depositing User: | Dr Aliya Al-Hosni |
| Unique ID: | glathesis:2017-8118 |
| Copyright: | Copyright of this thesis is held by the author. |
| Date Deposited: | 18 Apr 2017 15:55 |
| Last Modified: | 16 Feb 2020 18:52 |
| URI: | https://theses.gla.ac.uk/id/eprint/8118 |
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