Targeted delivery of biological agents

Greig, Jenny A. (2009) Targeted delivery of biological agents. PhD thesis, University of Glasgow.

Abstract

Biological agents, including peptides and gene delivery systems (recombinant adenoviral vectors), suffer from a relative lack of native targeting capacity. Improvement of their targeting capacity could significantly increase the efficiency of these agents to provide therapeutic effects. Selective targeting of an anti-oxidant peptide to the vasculature in the SHRSP and administration of a variety of adenovirus (Ad) 35-based vectors into transgenic mice has lead to a significant enhancement in both the effectiveness of the anti-oxidant treatment and increased understanding of the requirements needed for the generation of a successfully targeted Ad35 vector. This helps understanding of the requirements for a successful treatment for cardiovascular disease and cancer.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Adenovirus, Anti-oxidant, Targeting
• Subjects: Q Science > QH Natural history > QH301 Biology
• Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
• Supervisor's Name: Baker, Professor Andrew H. and Work, Dr. Lorraine M.
• Date of Award: 2009
• Depositing User: Miss Jenny A. Greig
• Unique ID: glathesis:2009-1386
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 15 Jan 2010
• Last Modified: 10 Dec 2012 13:38
• URI: http://theses.gla.ac.uk/id/eprint/1386