Recombinant Surface Glycoproteins of Feline Leukaemia Virus

Ramsey, Ian Keith (1993) Recombinant Surface Glycoproteins of Feline Leukaemia Virus. PhD thesis, University of Glasgow.

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Feline leukaemia virus (FeLV) is a major cause of degenerative and proliferative diseases of myeloid, lymphoid and erythroid origin in domestic cats. The envelope of FeLV, which is a typical retrovirus, is studded with a transmembrane protein (TM) that anchors an external surface glycoprotein (SU). The FeLV SU (gp70) carries both neutralising epitopes and subgroup phenotypic determinants. FeLV occurs naturally in 3 subgroups, which are defined by a superinfection interference assay, suggesting that three FeLV cellular receptors exist, one for each subgroup. The regions of SU which determine the A/C phenotype have been defined as lying in a small variable region towards the amino terminus of the protein.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Adviser: Oswald Jarrett
Keywords: Virology, Veterinary science
Date of Award: 1993
Depositing User: Enlighten Team
Unique ID: glathesis:1993-74565
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 13 Nov 2019 15:58
Last Modified: 13 Nov 2019 15:58

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