Recombinant Surface Glycoproteins of Feline Leukaemia Virus

Ramsey, Ian Keith (1993) Recombinant Surface Glycoproteins of Feline Leukaemia Virus. PhD thesis, University of Glasgow.

Abstract

Feline leukaemia virus (FeLV) is a major cause of degenerative and proliferative diseases of myeloid, lymphoid and erythroid origin in domestic cats. The envelope of FeLV, which is a typical retrovirus, is studded with a transmembrane protein (TM) that anchors an external surface glycoprotein (SU). The FeLV SU (gp70) carries both neutralising epitopes and subgroup phenotypic determinants. FeLV occurs naturally in 3 subgroups, which are defined by a superinfection interference assay, suggesting that three FeLV cellular receptors exist, one for each subgroup. The regions of SU which determine the A/C phenotype have been defined as lying in a small variable region towards the amino terminus of the protein.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: Oswald Jarrett
• Keywords: Virology, Veterinary science
• Date of Award: 1993
• Depositing User: Enlighten Team
• Unique ID: glathesis:1993-74565
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 13 Nov 2019 15:58
• Last Modified: 13 Nov 2019 15:58
• URI: https://theses.gla.ac.uk/id/eprint/74565