Modulation of the Androgen Receptor by Hyperthermia in Human Prostate Cancer Cell Lines

Hocken, Alison (1994) Modulation of the Androgen Receptor by Hyperthermia in Human Prostate Cancer Cell Lines. PhD thesis, University of Glasgow.

Abstract

Many types of tumour cells are more sensitive to elevated temperatures than normal cells. This observation and the accessibility of the prostate gland to an external heat source has led to the development of thermotherapy as a treatment for prostate disease. One possible problem with this type of therapy is the development of thermotolerance. Thermotolerance is the acquisition of a resistance to a thermokilling temperature by pre-exposure of the cell to a sublethal dose of heat and is due to an increased level of a group of proteins known as heat shock proteins (hsp). One of the members of the hsp family is hsp90. Hsp90 is associated with steroid receptors and forms part of the unactivated 8S receptor. Work described in this thesis has shown that thermotolerance in three prostate cancer cell lines (LNCaP, DU145 and PCS) is a transient property which can be established by pre-exposing the cells to 39

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: Robin Leake
• Keywords: Molecular biology, Cellular biology
• Date of Award: 1994
• Depositing User: Enlighten Team
• Unique ID: glathesis:1994-75693
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 19 Nov 2019 18:56
• Last Modified: 19 Nov 2019 18:56
• URI: https://theses.gla.ac.uk/id/eprint/75693