Developing Novel Synthetic Methods for the Pauson-Khand Reaction

Blunt, Gillian (2002) Developing Novel Synthetic Methods for the Pauson-Khand Reaction. PhD thesis, University of Glasgow.

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The Pauson-Khand cyclisation is one of the most useful reactions for the formation of cyclopentenone ring systems. It is a [2 + 2 + 1] cycloaddition between an alkyne, alkene and one molecule of carbon monoxide. The reaction is mediated by dicobalt octacarbonyl. The aim was to develop a general and simple route to generating cyclopentenone ring systems utilising the Pauson-Khand cyclisation. We chose to use amines as promoters as opposed to the more commonly used amine N-oxides. An efficient route to cyclopentenone i was developed. Substrate ii was heated to 50

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Additional Information: Adviser: Jennifer Matthews
Keywords: Organic chemistry
Date of Award: 2002
Depositing User: Enlighten Team
Unique ID: glathesis:2002-76215
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 19 Nov 2019 16:28
Last Modified: 19 Nov 2019 16:28

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