Currie, Susan
(1992)
The Regulation of Phospholipase A2 Activity in Mitogen-Stimulated Swiss 3T3 Fibroblasts.
PhD thesis, University of Glasgow.
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Abstract
A variety of agonists that stimulate inositol phospholipid turnover also activate phospholipase A2 (PLA2). This study examines the possibility that bombesin, a well-characterised calcium-mobilising peptide mitogen, may fulfil this criterion. The profile of arachidonic acid (AA) release, as well as the regulatory mechanism(s) behind bombesin-stimulated PLA2 activity, were examined. It was found that the AA released upon bombesin stimulation, was composed of two phases - an initial transient phase that is essentially independent of extracellular calcium and of PKC activation and a later, sustained phase that is absolutely dependent on extracellular calcium and shows a requirement for PKC activation. This study focusses on the first of these phases and the regulatory mechanism involved in release.
| Item Type: |
Thesis
(PhD)
|
| Qualification Level: |
Doctoral |
| Keywords: |
Biochemistry |
| Date of Award: |
1992 |
| Depositing User: |
Enlighten Team
|
| Unique ID: |
glathesis:1992-77322 |
| Copyright: |
Copyright of this thesis is held by the author. |
| Date Deposited: |
14 Jan 2020 11:53 |
| Last Modified: |
14 Jan 2020 11:53 |
| URI: |
http://theses.gla.ac.uk/id/eprint/77322 |
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