Functional Hyperaemia of Skeletal Muscle

Hamilton, Ian Jack Donald (1987) Functional Hyperaemia of Skeletal Muscle. MSc(R) thesis, University of Glasgow.

Abstract

1. Blood flow was recorded through the cat gastrocnemius and soleus muscles at rest and during stimulation at physiological frequencies. Deficiencies in the experimental set-up are discussed and the results compared with the findings of other workers who have recorded blood flow through "fast" and "slow" muscle. 2. ATP and adenosine were shown to be vasodilators of the vascular bed of the cat gastrocnemius and soleus muscles. Potassium, hypertonic glucose and inorganic phosphate were not vasodilator. These findings are discussed in relation to the identity of the vasodilator agent in functional hyperaemia of skeletal muscle. 3. ATP was detected in the plasma and Krebs perfusate from the resting and stimulated cat soleus muscle. This is discussed in relation to the hypothesis that ATP could be the vasodilator agent in functional hyperaemia. 4. APT was shown to be rapidly removed from cat blood in vitro. This is discussed in relation to a possible extracellular role for ATP.

• Item Type: Thesis (MSc(R))
• Qualification Level: Masters
• Keywords: Physiology
• Date of Award: 1987
• Depositing User: Enlighten Team
• Unique ID: glathesis:1987-77656
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 11:53
• Last Modified: 14 Jan 2020 11:53
• URI: https://theses.gla.ac.uk/id/eprint/77656