The Influence of the Autonomic Nervous System in Psoriasis

Leslie, George (1948) The Influence of the Autonomic Nervous System in Psoriasis. PhD thesis, University of Glasgow.

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1). A review of 186 cases of Psoriasis is given. 2). 100 cases had roentgen-rays applied to the Lumbar and Cervical Sympathetic Enlargements. 83 cases (83%) responded (the eruption cleared or improved); 17 cases (17%) were unimproved, 3). 84 cases had carbachol administered by mouth. 64 cases (76.2%) responded (the eruption cleared or improved); 20 cases (23.8%) were unimproved. 4). 2 cases had Carbachol administered by intramuscular injection. There was no response before the onset of mild signs of intolerance to the drug. 5). 6 cases failing to respond to Carbachol orally and to Spinal Radiation were given Thiamin hydrochloride by mouth. 1 case cleared completely and the others were improved 6). The results in the series of cases given Carbachol, a substance which reproduces the effects of stimulation of the Autonomic Nervous System, show that this System plays an active role in Psoriasis. 7). The almost identical results observed in the Spinal Radiation series is evidence that the action of the roentgen-rays is on the Autonomic Nervous System. 8). It has been suggested that this action is on the sympathetic end branches to the skin, which in turn produces a reflex action on the sympathetic ganglia. 9). It has been shown that Thiamin, another chemical intermediary of the Autonomic Nervous System, may also have a beneficial influence in Psoriasis.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Keywords: Neurosciences
Date of Award: 1948
Depositing User: Enlighten Team
Unique ID: glathesis:1948-79702
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 04 Mar 2020 15:24
Last Modified: 04 Mar 2020 15:24

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