An investigation of the relationship between the inflammatory response and outcome in patients with gastro-oesophageal cancer

Crumley, Andrew B.C. (2011) An investigation of the relationship between the inflammatory response and outcome in patients with gastro-oesophageal cancer. MD thesis, University of Glasgow.

Abstract

The thesis reviews the literature regarding the relationship between the local and systemic inflammatory responses and outcome in patients with gastro-oesophageal cancer. The study chapters then examine the relationship between the systemic inflammatory response and survival, in operable and inoperable disease and within, a cohort treated with palliative chemotherapy. The local inflammatory response and its relationship with tumour related factors, the systemic inflammatory response and survival, was examined in patients who underwent potentially curative surgery Also, the clinical utility of a systemic inflammation based score (Glasgow Prognostic Score) as a part of clinical staging, was then examined. The importance of these studies in a scientific and clinical context are discussed. Future work is also discussed.

• Item Type: Thesis (MD)
• Qualification Level: Doctoral
• Keywords: Gastric, oesophageal, cancer, survival, systemic inflammatory response, local inflammatory response
• Subjects: R Medicine > RD Surgery
• Colleges/Schools: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Supervisor's Name: McMillan, Prof. Donald C.
• Date of Award: 2011
• Depositing User: Mr Andrew Crumley
• Unique ID: glathesis:2011-2584
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 25 May 2011
• Last Modified: 10 Dec 2012 13:57
• URI: https://theses.gla.ac.uk/id/eprint/2584