Plasticity related gene expression in the hippocampus

Roberts, Lindsay A. (1996) Plasticity related gene expression in the hippocampus. PhD thesis, University of Glasgow.

Abstract

Learning and the retention of the information as a memory produces changes in synaptic efficiency, the formation of new synapses and remodelling of existing synapses in the central nervous system. These plasticity-related changes are brought about by the modification of existing proteins and the synthesis of new proteins. One structure in the brain which is particularly associated with learning and memory is the hippocampus. Manipulation of synaptic transmission in this structure (in particular the phenomenon of long-term potentiation or LTP) is widely believed to be the mechanism which underlies mammalian synaptic plasticity This work was undertaken to further investigate the proteins which are affected by plasticity-related changes within the hippocampus, to improve understanding of why these changes occur and uncover more details about the mechanisms involved.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Keywords: Neurosciences.
• Colleges/Schools: College of Medical Veterinary and Life Sciences
• Supervisor's Name: O’Shaughnessy, Dr. Celestine
• Date of Award: 1996
• Depositing User: Enlighten Team
• Unique ID: glathesis:1996-71716
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 17 May 2019 09:31
• Last Modified: 16 Aug 2022 09:13
• Thesis DOI: 10.5525/gla.thesis.71716
• URI: https://theses.gla.ac.uk/id/eprint/71716