Venous thrombosis and women's health: Identification of risk factors and long terms effects

McColl, Mark D. (1999) Venous thrombosis and women's health: Identification of risk factors and long terms effects. MD thesis, University of Glasgow.

Abstract

Venous thromboembolism (VTE) remains an important cause of morbidity and mortality, with well-recognised inherited and acquired risk factors. Women are particularly at risk of this condition because of pregnancy, the use of combined oral contraceptive pills, and hormone replacement therapy. A number of long-term sequelae may occur following an episode of VTE in women, such as development of the post- thrombotic syndrome, restriction of future contraceptive choice, bleeding events related to anticoagulants, and recurrence of thrombosis. In recent years there has been a marked increase in our understanding of genetic risk factors important for the development of VTE, and of their interaction with acquired risks. In particular, the description of the factor V Leiden and (more recently) prothrombin 202 lOA mutations have highlighted common genetic variations that are associated with a modest increased risk of thromboembolism. These genetic mutations may also be associated with other conditions that are associated with coagulation activation, such as preeclampsia. Thrombophilia is a rapidly expanding and complex field, and undoubtedly new abnormalities will be described within the next few years.

• Item Type: Thesis (MD)
• Qualification Level: Doctoral
• Additional Information: Advisers: Dr Isobel D Walker, Professor Ian A. Greer and Dr R.C. Tait.
• Keywords: Physiology.
• Subjects: Q Science > QP Physiology
• Colleges/Schools: College of Medical Veterinary and Life Sciences
• Date of Award: 1999
• Depositing User: Enlighten Team
• Unique ID: glathesis:1999-71818
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 17 May 2019 09:31
• Last Modified: 26 Oct 2022 08:57
• Thesis DOI: 10.5525/gla.thesis.71818
• URI: https://theses.gla.ac.uk/id/eprint/71818