Verapamil and Polyunsaturated Fatty Acids As Resistance Modulators In Vitro

Luo, Weihua (1992) Verapamil and Polyunsaturated Fatty Acids As Resistance Modulators In Vitro. PhD thesis, University of Glasgow.

Abstract

The development of resistance is thought to be a major cause of treatment failure in cancer patients. Multidrug resistance is a form in which tumour cells develop cross-resistance to a range of natural products. This is commonly associated with increased expression of P- glycoprotein, which appears to act as a membrane efflux pump. The aims of the present studies were firstly to further characterise the mechanisms by which verapamil can sensitise resistant tumour cells to cytotoxic drugs, and secondly to investigate polyunsaturated fatty acids as an alternative means of sensitising drug resistant cell lines.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: Jane Plumb
• Keywords: Medicine, Pharmacology, Oncology
• Date of Award: 1992
• Depositing User: Enlighten Team
• Unique ID: glathesis:1992-74445
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 27 Sep 2019 18:20
• Last Modified: 27 Sep 2019 18:20
• URI: https://theses.gla.ac.uk/id/eprint/74445