The Phenotypic Consequences of Genetic Variation in the Modulatory Domain of the Rat Glucocorticoid Receptor

Heeley, Robert P (1998) The Phenotypic Consequences of Genetic Variation in the Modulatory Domain of the Rat Glucocorticoid Receptor. PhD thesis, University of Glasgow.

Abstract

Previous investigations have reported differences in the affinity of hepatic glucocorticoid receptors (GR) for glucocorticoids between the Milan hypertensive (MHS) and normotensive (MNS) strains (Kenyon et al., 1994), the Zucker lean and obese strains (White and Martin, 1990) and hypertensive SHR and normotensive WKY strains of rat (Panarelli et al., 1995). To determine the possible causes of this phenotypic variation, a series of investigations were carried out into the molecular genetics of strain specific allelic variants of rat GR.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: C J Kenyon
• Keywords: Genetics
• Date of Award: 1998
• Depositing User: Enlighten Team
• Unique ID: glathesis:1998-74490
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 27 Sep 2019 18:08
• Last Modified: 27 Sep 2019 18:08
• URI: https://theses.gla.ac.uk/id/eprint/74490