A Mutational Analysis of the DNA Binding Domain of the Herpes Simplex Virus Immediate Early Protein Vmw175

Allen, Kathryn Elizabeth (1993) A Mutational Analysis of the DNA Binding Domain of the Herpes Simplex Virus Immediate Early Protein Vmw175. PhD thesis, University of Glasgow.

Abstract

Upon infection, HSV-1 genes are transcribed by the host cell RNA polymerase II. The analysis of polypeptides synthesized during the course of HSV-1 lytic infection led to the identification of three co-ordinately regulated groups of genes, characterized by their specific temporal expression. The immediate-early or alpha genes are synthesized immediately following infection. Synthesis of immediate-early polypeptides is followed by the expression of early or beta genes, whilst the synthesis of late or gamma genes occurs subsequent to the onset of viral DNA synthesis.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Additional Information: Adviser: Roger D Everett
• Keywords: Virology
• Date of Award: 1993
• Depositing User: Enlighten Team
• Unique ID: glathesis:1993-74558
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 27 Sep 2019 17:48
• Last Modified: 27 Sep 2019 17:48
• URI: https://theses.gla.ac.uk/id/eprint/74558