Mechanisms for Anaesthetic Mediated Changes in Drug Disposition

Reilly, Charles Stewart (1989) Mechanisms for Anaesthetic Mediated Changes in Drug Disposition. MD thesis, University of Glasgow.

Abstract

Anaesthesia may alter acutely the disposition of drugs in the body. This may be produced by changes in hepatic blood flow, by changes in hepatic drug-metabolising enzyme activity or by changes in the distribution of the drug in the body. The known effect of anaesthesia on these determinants is described. The control of and factors affecting hepatic blood flow are discussed, as are the methods of measuring it. Hepatic drug metabolising enzymes are described. Their activity, mathematical models,methods of assessment and factors altering activity are discussed.

• Item Type: Thesis (MD)
• Qualification Level: Doctoral
• Keywords: Medicine, Pharmacology
• Date of Award: 1989
• Depositing User: Enlighten Team
• Unique ID: glathesis:1989-76884
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 14 Jan 2020 09:29
• Last Modified: 14 Jan 2020 09:29
• URI: https://theses.gla.ac.uk/id/eprint/76884