An investigation into aortic calcification and its relevance to short- and long-term outcome following colorectal cancer resection

Knight, Katrina A. (2021) An investigation into aortic calcification and its relevance to short- and long-term outcome following colorectal cancer resection. PhD thesis, University of Glasgow.

Abstract

Cardiovascular disease and colorectal cancer are major causes of death worldwide. The interaction between host and tumour in patients with operable colorectal cancer may be influenced by the presence of cardiovascular disease. Recently, the burden of abdominal aortic calcification has been identified as a potential driver of inferior outcome following abdominal surgery. The present thesis systematically examines the relationship between the degree of aortic calcification and outcome following elective colorectal cancer resection with particular focus on: • Derivation and validation of an objective score reflecting the burden of calcification • The relationship between the degree of aortic calcification, postoperative complications and survival • Response to radiotherapy and tolerance and completion of adjuvant chemotherapy • The degree of tumour hypoxia evident on immunohistochemical staining • Potential mediating factors including the presence of systemic inflammation and comorbidity • The correlation between aortic calcification and dynamic measures of cardiorespiratory fitness • The use of a novel imaging technique for preoperative assessment of mesenteric flow.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Colleges/Schools: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Supervisor's Name: Roxburgh, Dr. Campbell and Park, Mr. James
• Date of Award: 2021
• Depositing User: Theses Team
• Unique ID: glathesis:2021-83004
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 22 Jun 2022 09:14
• Last Modified: 23 Jun 2022 13:29
• Thesis DOI: 10.5525/gla.thesis.83004
• URI: https://theses.gla.ac.uk/id/eprint/83004

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