Feng, Junjie (2017) ISG expression screening reveals the family-specific antibunyaviral activity of ISG20. PhD thesis, University of Glasgow.
Due to Embargo and/or Third Party Copyright restrictions, this thesis is not available in this service.Abstract
Order Bunyavirales poses a significant threat to the agricultural industry, animal husbandry and human welfare. In response to viral infections, interferons (IFNs) trigger the expression of numerous interferon stimulated genes (ISGs) whose concerted action can potently inhibit the replication of bunyaviruses. We used a FACS-based method to screen the ability of ~500 unique ISGs from humans or rhesus macaques to inhibit the replication of Bunyamwera virus (BUNV), the prototype of both the Peribunyaviridae family and Bunyavirales order. Candidates possessing antibunyaviral activity were further examined using a panel of divergent bunyaviruses in family Peribunyaviridae, Hantaviridae, Nairoviridae and Phenuiviridae.
| Item Type: | Thesis (PhD) |
|---|---|
| Qualification Level: | Doctoral |
| Keywords: | Bunyaviruses, innate immunity, ISGs screen, ribonuclease, in vitro evolution. |
| Subjects: | Q Science > QR Microbiology > QR355 Virology |
| Colleges/Schools: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Funder's Name: | Wellcome Trust (WELLCOTR), Medical Research Council (MRC), Medical Research Council (MRC) |
| Supervisor's Name: | Wilson, Dr. Sam, Shi, Dr. Xiaohong and Elliott, Prof. Richard |
| Date of Award: | 2017 |
| Embargo Date: | 29 November 2020 |
| Depositing User: | Mr Junjie Feng |
| Unique ID: | glathesis:2017-8610 |
| Copyright: | Copyright of this thesis is held by the author. |
| Date Deposited: | 05 Dec 2017 13:47 |
| Last Modified: | 04 Dec 2019 16:19 |
| URI: | https://theses.gla.ac.uk/id/eprint/8610 |
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