Cellular strategies to promote repair in the damaged CNS using a combined therapeutic approach

Lamond, Rebecca (2013) Cellular strategies to promote repair in the damaged CNS using a combined therapeutic approach. PhD thesis, University of Glasgow.

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Abstract

Following disease or injury to the CNS, the formation of a glial scar represents a physical and molecular barrier to repair. Although some therapies have promoted axonal sprouting into the lesion site, these fibres are often tangled and disorientated. To date, there has been little evidence of regenerating fibres successfully exiting the glial scar to reform functional connections. Furthermore, remyelination after disease or injury is limited, often consisting of shorter internodes of myelin and thinner sheaths. Thus, potential therapies aimed at enhancing CNS repair should support the outgrowth of neurites, guide their exit from the glial scar and perhaps aid remyelination. Since multiple factors impede the regeneration of the CNS, a combinatorial approach to therapies including cell-transplantation may be a more promising strategy.

Item Type: Thesis (PhD)
Qualification Level: Doctoral
Subjects: Q Science > QR Microbiology > QR180 Immunology
Colleges/Schools: College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Funder's Name: UNSPECIFIED
Supervisor's Name: Barnett, Prof. Susan
Date of Award: 2013
Depositing User: Mrs Marie Cairney
Unique ID: glathesis:2013-4481
Copyright: Copyright of this thesis is held by the author.
Date Deposited: 22 Jul 2013 10:00
Last Modified: 18 Jul 2016 08:33
URI: http://theses.gla.ac.uk/id/eprint/4481

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