Cellular strategies to promote repair in the damaged CNS using a combined therapeutic approach

Lamond, Rebecca (2013) Cellular strategies to promote repair in the damaged CNS using a combined therapeutic approach. PhD thesis, University of Glasgow.

Abstract

Following disease or injury to the CNS, the formation of a glial scar represents a
physical and molecular barrier to repair. Although some therapies have promoted
axonal sprouting into the lesion site, these fibres are often tangled and
disorientated. To date, there has been little evidence of regenerating fibres
successfully exiting the glial scar to reform functional connections. Furthermore,
remyelination after disease or injury is limited, often consisting of shorter
internodes of myelin and thinner sheaths. Thus, potential therapies aimed at
enhancing CNS repair should support the outgrowth of neurites, guide their exit
from the glial scar and perhaps aid remyelination. Since multiple factors impede
the regeneration of the CNS, a combinatorial approach to therapies including
cell-transplantation may be a more promising strategy.

• Item Type: Thesis (PhD)
• Qualification Level: Doctoral
• Subjects: Q Science > QR Microbiology > QR180 Immunology
• Colleges/Schools: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Supervisor's Name: Barnett, Prof. Susan
• Date of Award: 2013
• Depositing User: Mrs Marie Cairney
• Unique ID: glathesis:2013-4481
• Copyright: Copyright of this thesis is held by the author.
• Date Deposited: 22 Jul 2013 10:00
• Last Modified: 18 Jul 2016 08:33
• URI: https://theses.gla.ac.uk/id/eprint/4481